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Title : BIOASSAY OF BRINE SHRIMP LETHALITY, CARDIOPROTECTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF METHANOLIC LEAF EXTRACT OF FICUS BENJAMINA
Authors : Md. Irfan Amin Chowdury, Mohammad Nazmul Alam, Dewan Shakibuzzaman, Galib Ahsan, Rajesh Barua, Md. Faruky Azam Chowdhury, Muhammad Moin Uddin Mazumdar, Md. Rabiul Islam
Abstract :

Brine shrimp lethality bioassay, clot lysis and hypotonicity induced membrane lysismethod was used to evaluate the cytotoxic,cardioprotective and anti-inflammatory activity of methanolicextract of Ficus benjamnia. The extract showed moderate cytotoxic activity. LC50 value of the extract was 232.71µg/ml, which was compared with vincristine sulphate (12.59µg/ml). Methanolic leaf extract of Ficus benjamina was treated with human blood to evaluate Cardioprotective effect. It showed promising Cardioprotective activity which was about (34.95± 1.98)% compared to streptokinase which was used as standard (63.54 ± 2.61)%. In the case of anti-inflammatory study, methanolic leaf extract showed (20.79±1.07)% and (58.06±1.03)%of membrane stabilization activity at 31.25µg/ml and 1000 µg/ml concentration respectively.

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