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Title : A RETROSPECTIVE STUDY ON EVALUATION OF COMPARATIVE EFFICACY BETWEEN THREE COMBINATIONAL THERAPIES FOR TYPE 2 DIABETES MELLITUS
Authors : Malarkodi Velraj, Poripiraddy Satya Prasad, Dr. V. Ravichandiran, Dr.A.PanneerSelvam, Ragesh G
Abstract : Diabetes is a condition in which the body either does not produce enough, or does not properly respond to insulin - a hormone produced in the pancreas. Insulin enables cells to absorb glucose in order to turn it into energy. In diabetes, the body either fails to properly respond to its own insulin, does not make enough insulin or both. This causes glucose to accumulate in the blood often leading to various complications. This study mainly focused on Evaluation of efficasy between the combinations therapies for Type 2 Diabetes Mellitus. The aim were achieved through monitoring the blood sugar parameters, to assess the changes in glycemic control in patients with diabetes mellitus. It’s a retrospective study. Overall the study results conclude that a combination of Metformin with Acarbose, Glimepiride and Sitagliptin therapy have greater impact on control of FBS, PPBS and HbA1c, on the other hand Metformin and sitagliptin combination reveals significant reduction in FBS, PPBS and HbA1c in diabetic patients compare with Metformin + Acarbose and Metformin + Glimepiride therapies. Many research articles also conclude that metformin therapy with sitagliptin have more impression on diabetic control.

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