||Typhoid fever is one such disease, still remains a serious problem and a major threat to the society in most of the developing countries. In our search for therapeutic agents from natural sources with potential for the treatment of typhoid fevers, this work aims to evaluate the in vivo antisalmonellal activity and the effect of bacterial infection on tissues oxidation of aqueous extract of Albizia gummifera. The Salmonella typhi-infected rats concurrently received different doses of plant extract (20, 40 and 80 mg/kg bw) or oxytetracyclin (5 mg/kg) daily for 9 days. The parameters such as, catalase peroxidase, nitric oxide, lipid peroxidation index, malondialdehyde, alkaline phosphatase and bilirubin were assessed. Results obtained showed that groups of treated animals at 20, 40 and 80 mg/kg bw of extract were healed respectively after 8, 7 and 6 days of treatment for females and after 9, 7 and 7 days of treatment for males. Antioxidant activity has shown that CAT (male) and peroxidase (both sex) activities for treated animals were increased significantly (p < 0.05) compared to the untreated control group animals while NO, MDA, ALP and bilirubin levels were significantly decreased (p > 0.05). Increase and reduction of theses antioxidants parameters to their normal value (that of the neutral control) was doses-dependent manner. The overall results of this study indicate that aqueous extract of Albizia gummifera exhibited in different in vivo systems, strong antisalmonellal activity and antioxidant activity on cell oxidation induced by infection with Salmonella typhi.