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Title : Surface modified liposomes for targeted drug delivery
Authors : Anupama Puntambekar, Amrita Bajaj, Pranita Savardekar
Abstract : The aim of the present study was to design and develop a suitable intranasal spray formulation of surface modified liposomes to improve the concentration of anti-psychotic drug into the brain tissue for therapy of schizophrenia. Liposomal spray solution was optimized; particle size, zeta potential and polydispersity index were measured using Malvern Zetasizer. Morphology of liposomal spray droplets was examined using scanning electron microscopy. Drug diffusion studies were performed and drug diffused was estimated using UV spectroscopic analysis. Stable liposomal spray was formulated. The optimized liposomal spray showed uniform vesicles in the size range 155-170 nm and zeta potential of optimized formulation was found to be 29.77. Surface coating was done using chitosan solution in glacial acetic acid and evaluated. Intranasal surface modified liposomal spray exhibited higher deposition in brain tissues compared to conventional solution after intranasal and intramuscular administration indicating potential for nose to brain targeting. Thus nasal drug delivery offers a viable alternative to oral and injectable routes of administration.

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