||SMEDDS are defined as mixtures of oils, co-solvents and surfactants, which is isotropic in nature and which spontaneously emulsify to produce fine oil-in-water emulsions when introduced into aqueous phase under mild agitation. After oral delivery of BCS class-II drugs, over one-half of the drug compounds are diminished in the gastrointestinal (GI) tract. BCS class-II drugs having less water solubility and dissolution there by low bioavailability and this is a major issue face by the pharmaceutical industries. For the treatment of chronic diseases, delivery of poorly soluble drugs by SMEDDS as a vehicle via oral route which may enhances the bioavailability. Researchers are focusing on novel formulations of SMEEDS for various diseases having promising in-vitro and in-vivo results. Thus, this current review provides a brief updated collection of information about SMEDDS, its novel applications and future prospective.