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Title : CO-CRYSTAL CHARACTERIZATION OF NICOTINAMIDE AND UREA
Authors : Yutaka Inoue, Hirotaka Onoda, Hiroyasu Sato, Isamu Murata, Ikuo Kanamoto
Abstract :

Aim of this study, a co-crystal (nicotinamide and urea) was prepared, and it was used to investigate the relevance of single-crystal structure analysis in combination with other measurement techniques. Results of both single-crystal X-ray diffraction and powder X-ray diffraction confirmed that the nicotinamide and urea co-crystals had a molar ratio of 2/1 and comprised a monoclinic system. Results of differential scanning calorimetry showed that the melting point of the co-crystals was different from that of nicotinamide and urea alone. Results of Fourier transform infrared (FT-IR) absorption spectrometry showed that the co-crystals interacted between nicotinamide and urea due to amino group. Scanning electron microscopy results showed that the co-crystal and nicotinamide and urea alone have different appearances. Thus, the combination of single-crystal structure analysis with other measurement methods is very useful for analyzing the crystal structure in detail.

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