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Title : DEVELOPMENT OF A LIQUID CHROMATOGRAPHIC METHOD FOR PHARMACOKINETIC STUDIES OF TOLTERODINE TARTRATE ORODISPERSIBLE TABLETS IN RATS
Authors : Y Padmavathi, Sumedha Kapre, K Latha, Renuka Menda, Rohini Kagithala
Abstract :

A selective and high throughput reverse phase liquid chromatographic method was developed for studying pharmacokinetics of tolterodine tartrate (TT) orodispersible tablets (ODT) in rats. Quantification is achieved by the peak-area ratio method with reference to the internal standard. Metaxalone was used as internal standard. After liquid- liquid extraction the analyte and the internal standard were chromatographed on Enable 18H (5µ, 250×4.6mm) C18 column. Mobile phase used consists of phosphate buffer pH 3 and acetonitrile (55:45 %v/v). The elute was monitored with the UV–VIS detector at 280 nm with a flow rate of 0.8 mL/min. The peaks of the drug and IS were obtained at retention times of 6.74 min and 10.5 min respectively. The method was validated according to USFDA guidelines. The absolute recovery of analyte was consistent and reproducible. The method was successfully applied to study the pharmacokinetics of tolterodine tartrate orodispersible tablets in rats.
 

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