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Title : Spectrophotometric method for simultaneous estimation of Epalrestat and Methylcobalamin in pharmaceutical dosage form
Authors : Madhuri A. Hinge, Niraj K.Patel, Rajvi J. Mahida
Abstract :

A simple, accurate, and reproducible UV-spectrophotometric method has been developed for simultaneous estimation of Epalrestat and Methylcobalamin in tablet dosage form.  In Absorbance ratio method  ,two wavelengths 238 nm and 257.80 nm were used  over the concentration range of 50 - 250 µg/ml and 0.5 - 2.5 µg/ml for Epalrestat and Methylcobalamine respectively. Correlation coefficient found to be 0.9995.Accuracy for both the drugs were in the range of 98-101 %. The method was validated as per the International Conference on Harmonization (ICH) guidelines.

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