||Gastro Esophageal Reflux Disease (GERD) is a condition that occurs when the refluxed stomach contents lead to troublesome symptoms and complications. Prevalence of GERD differs in various geographical regions. Factors such as smoking, alcohol consumption, certain medications and foods have a significant effect on the aggravation of the diseaseA prospective observational study was conducted between August 2015 & January 2016 in department of Gastroenterology, Gandhi hospital, Secunderabad after approval from Institutional Ethical Committee, CMRCP. Cases included according to study criteria. A total of 2460 subjects participated, out of which 130 subjects were found to be affected with GERD. Data obtained from cases were analyzed to obtain final outcome by statistical analysis using ANOVA. The prevalence of GERD in males was 58.46%. 70.77% of the patients belonged to the age group of below 50 years. Alcoholism 36.93%, smoking 42.31%, tea consumption twice daily (47.69%), meat consumption 72.31% are the factors that aggravate disease. 99 patients who presented for second endoscopy were compared to know the efficacy of each proton pump inhibitors (Pantoprazole, Rabeprazole and Esomeprazole) considered in this study. Rabeprazole showing 37.81% symptomatic relief followed by esomeprazole 35.37% and pantoprazole 26.82%. several factors such as change in the diet, lifestyle, smoking and alcohol consumption can affect the prevalence of GERD in this rapidly progressing society. The prescribed proton pump inhibitors are well tolerated with Rabeprazole showing better efficacy than Esomeprazole and Pantoprazole for the relief of esophageal lesions and GERD related symptoms.