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Title : Structure Based Drug Design and Synthesis of Ibuprofen analogs as Cox Inhibitors
Authors : T.Umema Naaz, Shaheen Begum, Nameera Jabeen, Yerragunta Vishwanadham
Abstract :

Cyclooxygenase-2 (COX-2) is one of the important targets for treatment of inflammation related diseases. Structure based drug design was carried out for about 1000 molecules and then molecules having good interactions with 3NT1 protein were synthesized. According to the results of molecular docking, the synthesized novel ibuprofen schiff bases derivatives have selective COX-2 inhibition. In conclusion, the newly synthesized ibuprofen derivatives can be used in model in vivo studies.

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