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Title : DEVELOPMENT AND EVALUATION OF MICROSPONGE DRUG DELIVERY SYSTEM OF INDOMETHACIN
Authors : Inukonda Rajitha, Dr K. Umasankar, Dr. P. Jayachandra reddy
Abstract :

In the present study controlled release formulation of Indomethacin microsponges were prepared by using Carbopol 940, PVA. Microsponges were prepared by Quasi emulsion solvent diffusion method by changing drug polymer ratio (1:0.5-1:4) and process was optimized. Microsponges were evaluated by micromeritic properties, drug content, encapsulation efficiency, and particle size. Characterization of Indomethacin microsponges were done by FT-IR spectroscopy,. In-vitro dissolution study indicated that the release of Indomethacin varied according to the concentration of matrix forming polymer, drug  release mechanism was found to be super case II transport Therefore, Indomethacin microsponges prepared in thus study are promising as being more useful than conventional formulation intherapy.

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