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Title : DEVELOPMENT AND VALIDATION OF A RP-HPLC METHOD FOR ESTIMATION OF LAMOTRIGINE IN A TABLET DOSAGE FORM
Authors : Dr M. Paul Richard, Dr Kiran Kumar P.Govardhan Reddy, P.Uma Mahesh
Abstract :

A simple, sensitive, and precise high performance liquid chromatographic method for the analysis of Lamotrigine has been developed and validated for the  determination of compound in commercial pharmaceutical products. The compounds were well separated on BDS Hypersil C18 reverse phase column by the use of a mobile phase of mixed phosphate buffer and acetonitrile in a ratio of 40:60 v/v, at a flow rate of 1.0 ml/min with detection wavelength at 248nm. The method was validated in terms of linearity, precision, accuracy, and specificity, robustness and solution stability. The method does require only 10 minutes as runtime for analysis which prove the adoptability of the method for the routine quality control analysis of the drug.

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