||The present study was aimed to prepared and characterize gel formulations of ethyl acetate and methanolic extracts of Solanum pubescens (Solanaceae) leaves using different polymers as gelling agents in various concentrations and also to evaluate anti-inflammatory activity of gel. For the study, polymers such as Carbopol 940 (0.5%w/v), Hydroxy Propyl Methyl Cellulose K4M (2.5%w/v), Sodium Carboxy Methyl Cellulose (3.5%w/v) were selected for preparation of different gel formulations. The prepared gels were evaluated for physical appearance, pH, viscosity, extrudability, spreadability, anti inflammatory activity and also skin irritation to observe toxicity or side effects. At last the stability study performed to confirm the stability of final formulation. It was inferred from the results that gel formulation prepared by HPMC K4M found to be best formulations among the prepared batches. The prepared gels were evaluated for anti inflammatory activity by carrageenan induced paw odema method in wistar rat model using Diclofenac Sodium as the reference anti-inflammatory drug. And HPMC K4M formulation having 7.5%w/v ethyl acetate extract of Solanum pubescens (Solanaceae) leaves in gel shown significant inhibition in carrageenan induced paw odema.