Abstract

 View                 Download                 XML
Title ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF EFAVIRENZ USING LIQUI SOLID COMPACT TECHNIQUE
Authors Jagan Mohan Vatyam, Ch. S. Vijaya Vani, V. Umamaheshwara Rao
Description The objective of the present investigation is to formulate Liqui-Solid tablets of Efavirenz. In the present study Efavirenz immediate release tablets were prepared by using aid of non-volatile solvents like polyethylene glycol (PEG) and propylene glycol (PG), in which the poorly soluble drug is dissolved and thereby increasing its solubility and in turn dissolution rate. The tablets were formulated using direct compression technology by employing super disintegrants like cross povidone and sodium starch glycolate. The prepared liquid-solid compact tablets were evaluated for pre compression, post compression and in-vitro drug release. The in-vitro drug release pattern of liquisolid tablets of Efavirenz was fitted in kinetic model which showed highest regression i.e. for zero order kinetics. Among all the formulations, LS-12 which is a combination of Propylene glycol, Ratio (R) =2 and cross povidone- 4% was optimized based on desired immediate release time (10mins) followed by acceptable disintegration and drug release properties.

Back