Abstract

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Title PRECLINICAL BLOOD CHEMISTRY SAFETY PROFILE STUDIES OF \"ROHITAKARISTA\" ON THE KIDNEY FUNCTION AFTER CHRONIC ADMINISTRATION TO MALE SPRAGUE-DAWLEY RATS
Authors Md. Arif Hasan, Md. Rakib Hasan, Mohammad Jashim Uddin, Gulshanara Begum, Nawfel Abdullah, Md. Moklesur Rahman Sarker, Mohammed Motaher Hossain Chowdhury and M. S. K. Choudhuri
Description Rohitakarista (RHT) is an Ayurvedic preparation used as a traditional medicine in the treatment of splenomegaly. To find out the effect of chronic administration of RHT on serum blood chemistry profile, it was administered chronically to the male Sprague-Dawley rats at a dose of 40 ml/kg for 28 days. In this study, the albumin content was decreased (9.17 %) in RHT treated male rats and it was statistically significant (p=0.047), the globulin content was highly significantly (p=0.012) increased (53.10 %) as a result the decrease (43.18%) in the Albumin / Globulin (A/G) ratio was statistically highly significantly different from their corresponding control values (p=0.005). There were a statistically very highly significant (p=0.001) decrease of blood urea nitrogen (BUN) level (23.97%) and BUN/Creatinine ratio (21.62 %). It was observed that there was a 15.0% decrease  in serum uric acid content of RHT treated male rats in comparison to their control male rats which was also statistically significant (p=0.049).

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