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Title SCREENING OF IN-VITRO ANTIOXIDANT, BRINE SHRIMP LETHALITY BIOASSAY AND ANTIMICROBIAL ACTIVITIES OF EXTRACTS OF BRIDELIA RETUSA (L.) SPRENG. FRUIT
Authors Tufikul Islam, Mohammad Raquibul Hasan, Aumit Roy, Md. Shafiqul Islam, Md. Afaz Uddin, Md. Ariful Islam, Md. Nuruzzaman Neon, Md. Sohel Rana
Description The objective of present study was to investigate the antioxidant, brine shrimp lethality and antimicrobial activities of Bridelia retusa (L.) Spreng. fruit using n-hexane, ethyl acetate and methanol extracts. Several methods were used for assessing antioxidant activity. In total phenol content determination methanolic extract showed highest value of 134.5 mg/g as Gallic Acid Equivalent (GAE). N-hexane extract showed highest total flavonoid content with 60.50 Plus or Minus 4.95 mg/gm as Quarcetin Equivalent (QE). Methanolic extract showed highest tannin content with 652.50 Plus or Minus 3.53 mg/gm as Tannic Acid Equivalent (TAE) and total anti-oxidant capacity with 236.00 Plus or Minus 36.78 mg/gm as Ascorbic Acid Equivalent (AAE). Methanolic extracts showed good DPPH free radical scavenging activity with IC50 of 168.757 mg/mL. Ethyl acetate extract showed highest reducing capacity in CUPRAC test. Methanolic extracts showed good cytotoxic activity with IC50 value of 20 mg/ml in brine shrimp lethality bioassay. In antimicrobial assay extracts showed poor activity. Further studies are needed to isolate active compounds.

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