Abstract

 View                 Download                 XML
Title THE CARDIOACTIVE SCREENING OF THE EXTRACT FROM THE BARK OF STROPHANTHUS CUMINGII A.DC. (APOCYNACEAE) USING ISOLATED FROG HEART
Authors Maribeth R. Laurente, Mafel C. Ysrael
Description Strophanthus cumingii A. DC. (Apocynaceae) is one of two endemic Strophanthus species in the Philippines the bark of which is used as an arrow poison [1]. Strophanthus species used for this purpose are known to contain cardiac glycoside strophanthin in the bark and seeds [2]. This study determined the cardioactivity of the bark extract S. cumingii and its sub-fractions on isolated frog hearts. The hexane fraction was the most cardioactive with a maximum of 30.58% increase in the force of contraction and 38.24% increase in the frequency of contraction. The non-polar fraction of the crude extract from the bark of S. cumingii elicited a positive inotropic and negative chronotropic effect on the isolated frog hearts.

Back