Abstract

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Title ANTIPROTOZOAL AND MOLLUSCICIDAL ACTIVITIES OF PELARGONIUM GRAVEOLENS
Authors Eman Al-Sayed , Hoda Abdel Hamid , Hanaa M. Abu El Einin, Eman Ali, Zeinab Fahmy
Description <div style="text-align: justify">In this study, the ethanol extract of Pelargonium graveolens (PGE) exhibited a strong molluscicidal against Biomphalaria alexandrina snails, as well as a strong biocidal activity against the larval stages of Schistosoma &nbsp;mansoni (miracidia and cercariae). Treatment of the snails with the LC25 (59.7 ppm) of PGE induced a remarkable decrease in the protein levels in the snail tissues and hemolymph by 18 and 29%, respectively. A significant increase in the levels of the transaminases ALT (143%) and AST (161%) in the hemolymph was observed. Alkaline phosphatase was significantly increased by 124% in the snail tissues, while ACP was significantly increased by 76% in the hemolymph. PGE conferred the same inhibitory activity as metronidazole on Blastocystis hominis at a concentration of &nbsp;200 &micro;g/ml. The % mortality was 50, 60 and 70% after 24, 72 and 144 h incubation with PGE. The present study is the first report to provide evidence that PGE has a potent molluscicidal, biocidal and anti-Blastocystis effects.&nbsp;</div>

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