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Title Development and Validation of a stability indicating RP-HPLC method for simultaneous determination of Telmisartan, Chlorthalidone and Cilnidipine in pharmaceutical combined dosage forms
Authors Mathews Bommella, Ramisetti Nageswara Rao, Priyanka Peddi, Mukkanti Khagga, Sarbani pal
Description The study describes development and subsequent validation of a stability indicating reverse-phase HPLC method for simultaneous estimation of the Telmisartan, Chlorthalidone and Cilnidipine in combined solid dosage forms using RP-HPLC. Separation was accomplished on Kromasil 250 x 4.6 mm, 5mm C18 column using 0.1% OPA buffer and acetonitrile (57:43 v/v) as mobile phase pumped through at a flow rate of 1.2 ml/min at 30°C. Optimized wavelength was 238nm. Retention time of Telmisartan, Chlorthalidone and Cilnidipine were found to be 3.106min, 2.573min and 3.924 min respectively. %RSD of the Telmisartan, Chlorthalidone and Cilnidipine were found to be 0.87, 0.96 and 0.94 respectively. % recovery was obtained as 100.18%, 100.06% and 100.13% for Telmisartan, Chlorthalidone and Cilnidipine respectively. The proposed method also proved to be suitable as a rapid and reliable quality control method.

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