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Title DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR SIMULTANEOUS DETERMINATION OF OLMESARTAN MEDOXOMIL AND METOPROLOL SUCCINATE IN PHARMACEUTICAL PREPARATIONS
Authors *Sohan S. Chitlange*, Reshma A. Talole, Ramesh D. Bhusal and Monesh B. Nikumbh
Description Simple, accurate, and reproducible two UV-spectrophotometric methods have been developed for simultaneous estimation of Olmesartan Medoxomil (OLME) and Metoprolol Succinate (METO) in tablet dosage form. The first UV- Spectrophotometric method was a determination using the Area Under Curve method and the second UV method was a determination using the Multi-Component mode method at 256.5 nm and 222.0 nm over the concentration range 5-30 μg/mL and 5-30 μg/mL for OLME and METO respectively. Both UV-spectrophotometric methods were statistically validated and can be used for analysis of combined dose tablet formulation containing OLME and METO.

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