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|Title||ENHANCEMENT OF DISSOLUTION OF POORLY SOLUBLE RITONAVIR DRUG USING SYNTHETIC POLYMERS|
|Authors||A. Surendra, M. Jhansirani, R. Aruna, A.M.S. Sudhakar babu|
Development of solid dispersions of poorly water soluble drugs is one of the most widely used approaches to enhance the solubility as well as dissolution rate. In the current investigation, Ritonavir is selected as model drug to improve the solubility and dissolution rate by solid dispersion method. Solid dispersions were prepared using fusion method by incorporating carriers like polyethylene glycol 20000, Soluplus and Plasdone. Each carriers in different ratios (1:1, 1:2 and1:3) and evaluated for solubility studies, drug-carrier compatibility studies and in vitro dissolution studies. Based on the solubility and drug release studies, among all 10 formulations F10 formulation showed better drug release of 100% drug release at the end of 150th minute compared to other 8 formulations and plain Ritonavir formulation. So F10 (containing 1:3 ratio of PEG 20000) is the optimized formulation. In each case tablets prepared employing carriers gave higher dissolution rates as compared to the tablets prepared using pure drug. Hence solid dispersion in polymers can be used for enhancing the solubility and dissolution of Ritonavir.