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Title FORMULATION AND EVALUATION OF CONTROLLED POROSITY OSMOTIC DRUG DELIVERY SYSTEM OF METOPROLOL SUCCINATE
Authors Usha Sri T , Rajesh Vooturi, Vishnu P, Naveen Babu K
Description <div style="text-align: justify">Controlled porosity osmotic tablet of Metoprolol succinate prepared and evaluated in this study. Metoprolol succinate is very low soluble drug. So it is difficult to formulate osmotic tablet of Metoprolol succinate which gives drug release up to 24 hr at zero order. To get desired dissolution profile various formulation parameters like osmogen concentration, level of weight gain and level of pore former concentration were studied. Final optimized formulation was studied for effect of pH of dissolution media, agitation. There is no effect of pH of dissolution media and agitation intensity on dissolution. There is significant effect of osmotic pressure on dissolution confirms that prepared metoprolol succinate tablet gives drug release with osmotic mechanism.&nbsp;</div>

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