Abstract

 View                 Download                 XML
Title FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF RANOLAZINE
Authors *M Vanaja kumari, P Venkateswar reddy and M Sudhakar
Description The aim of the present study was to prepare and characterize the Sustained release matrix tablets of Ranolazine using Kollidon&reg; SR. Kollidon&reg; SR is a polyvinyl acetate based excipient. Three different strengths i.e 375mg, 500mg and 750mg of ranolazine SR tablets were prepared by direct compression method and by using common blend. The influence of compression force was studied on the dissolution release profile of Ranolazine SR tablets. In vitro release studies were performed for all the formulations using USP type II apparatus (paddle method) in 900 ml of 0.1N hydrochloric acid at 50 rpm for 24 hours and analyzed by UV spectrophotometer at 272nm. Further, in-vitro release pattern of drug from the optimized formulation was compared with innovator formulation and it was found to be super imposable with the Innovator product RANEXA based on dissimilarity and similarity factors. <br />

Back