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Title FORMULATION AND IN VITRO EVALUATION OF GASTRORETENTIVE BILAYER FLOATING TABLETS OF LOSARTAN POTASSIUM
Authors *Sruthi Buddharaju
Description The aim of present study was to formulate and evaluate Gastroretentive bilayer floating tablets of Losartan potassium using direct compression technology. Bilayer floating tablets comprised two layers, i.e. immediate release and controlled release layers. The immediate release layer comprised Crospovidone as a super disintegrant and floating layer comprised Sodium carboxy methyl cellulose (SCMC), Metolose SR and Sodium alginate as the release retarding polymers. Sodium bicarbonate was used as a gas generating agent. The powder blends were evaluated for pre-compression parameters. Compressed tablets were further evaluated for hardness, friability, weight variation, dimensions, Drug Content Uniformity, In-vitro buoyancy and dissolution studies. All the formulations showed good results which were compliance with pharmacopoeial standards. In-vitro dissolution studies were performed in USP-XXIII dissolution test apparatus, type II (paddle method) in 1.2pH buffer. More than 99% Losartan potassium of was released from the immediate release layer within 30 min. The results of dissolution studies indicated that formulation BFT8 (drug to polymer[SCMC] 1:0.25), the most successful of the study, exhibited drug release of approximately 98% at 12th hour with more than 12h buoyancy with floating lag time of 93seconds. An increase in drug release was observed on decreasing polymer ratio. The drug release mechanism of all the formulations was found to be Fickian diffusion-controlled drug release.

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