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Authors *Ethiraj T, Sujitha R, Ganesan V
Description The present research work is an attempt to develop and evaluate Nanosuspension of Glimepiride in order to improve the solubility and bioavailability of poorly water soluble drugs. Nanosuspensions of Glimepiride were developed with different ratios of Urea and PVP combinations by nanoprecipitation technique. Nanoprecipitation method being simple and less sophisticated was optimized for the preparation of nanosuspension. The Fourier transform infrared (FTIR) spectroscopy was used to confirm compatibility and to rule out any possible interactions between drug and carriers. Four formulations (F1, F2, F3 and F4) consisting PVP and urea in the ratios of 1:3 and 1:6 respectively were prepared. All formulations were prepared using poloxamer as stabilizer, mixture of drug and acetone as organic phase and distilled water containing carriers as aqueous phase. . Physicochemical characteristics of nanosuspension in terms of size, zeta potential, entrapment efficiency (% EE) and in vitro drug release were found within their acceptable ranges. Differential scanning calorimetry studies provided evidence that enhancement in solubility of drug resulted due to change in crystallinity of drug within the formulation. Data of in vitro release from nanosuspensions were fit in to different equations and kinetic models to explain release kinetics. <br />