Abstract

 View                 Download                 XML
Title INVITRO EVALUATION OF ANTIBACTERIAL ACTIVITY OF DIFFERENT SOLVENT EXTRACTS OF SECURIDACA LONGEPEDACULATA
Authors *Okoye EI, Ikegbunam MN, Amadi AK and Obi GE
Description The objective of the present study was to assess the antibacterial activity of different solvent extracts of Securidaca longependuculata. The  methanol, petroleum  ether  and  aqueous  extracts of  the  stem  bark of the plant were  examined  for  antibacterial activity  against Salmonella typhi, Escherichia coli, Staphylococcus aureus and Pseudomonas spp, using  the  agar well diffusion  method while the minimum inhibitory concentration of methanol extract was evaluated using agar dilution method. The extracts were graded into different concentrations of 100mg/ml, 50mg/ml, 25mg/ml and 12.5mg/ml. Results  showed  that  petroleum  ether  extract  had no antibacterial activity  while  the  aqueous   extracts showed the most  potent activity against Staphylococcus aureus (22.5mm at 100mg/ml) and Salmonella typhi (19mm at 100mg/ml), Escherichia coli (18.5mm at 100mg/ml) and Pseudomonas aeruginosa (17.5 at 100mg/ml). Methanol extract had the second highest activity against the test organisms. The MIC of the methanol extract against the test organisms were 100mg/ml for Staphylococcus aureus and ˃100mg/ml for the rest of the organisms tested. The entire evaluations showed that Securidaca longependuculata had antibacterial activity against clinical isolates tested.

Back