Abstract

 View                 Download                 XML
Title NEW VALIDATED METHOD FOR SIMULTANEOUS ANALYSIS OF METHYLPARABEN & PROPYLPARABEN IN POLYHERBAL FORMULATION (ORAL LIQUID DOSAGE FORM)
Authors Somia Gul, Kashifa Khanum and Nusrat Mujtaba
Description <div style="text-align: justify">An isocratic reversed phase high-performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous determination of methylparaben and propylparaben in poly herbal formulation at 254nm. Chromatographic separation was achieved on C18 WP, 100A column (250mm x 4.6 mm, 5 &micro;m) column using mobile phase, methanol: water: acetonitrile (40:40:20 v/v/v) having flow rate of 1.2 mL min -1 at room temperature. Calibration curves were linear over range of 40 &ndash; 60.2 &micro;g mL -1 of methylparaben with a correlation coefficient &plusmn; 0.99 and 7.9 &ndash; 11.9 &micro;g mL -1 of Propylparaben with coefficient correlation &plusmn; 0.99. &nbsp;Method is rapid, accurate, precise and specific for the routine quality control analysis of preservative content in poly herbal oral liquid dosage form.&nbsp;</div>

Back