Country-wise Listing - Bosnia

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S.NO Title & Authors Name page
1
BIOACTIVITY AND GENOTOXICITY OF CENTURIES OLD REMEDY ASPLENIUM SCOLOPENDRIUM L.
Una Glamočlija, Sanin Haverić, Jasmina Čakar, Adaleta Durmić, Anja Haverić, Kasim Bajrović
 Abstract                  View                 Download                 XML
Despite the fact that Asplenium scolopendrium L. is a wide spread fern which has been used as a human remedy for centuries, there are very poor or no data about activity and genotoxicity of A. scolopendrium extracts. In this work, vacuum dried water and ethanol extracts of A. scolopendrium fronds were tested for their antimicrobial, cytotoxic and genotoxic potential. Antimicrobial activity was evaluated by disk diffusion assay (concentration of extracts 35 mg/ml, 7 mg/ml and 1,4 mg/ml) and there was no inhibition zone for all extracts and for all microorganisms examined (Escherichia coli, Staphylococcus aureus and Candida albicans). Cytotoxic and genotoxic potential of extracts (70 mg/ml, 7 mg/ml and 0,7 mg/ml) was tested using cytokinesis-block micronucleus cytome assay in human lymphocyte cultures. Ethanol blocked division of cells in negative control so only water extracts were analyzed. Extracts didn’t show genotoxic properties but they showed weak cytotoxic properties. NDI (nuclear division index) decreased with increasing concentration of extracts, but there was no statistical significance when compared to negative control (p=0,055).
38-41
2
MELATONIN MEDIATES CLASSIC LACTOPEROXIDASES CATALYTIC MECHANISM
Semira Galijasevic, Elvisa Hodzic
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Lactoperoxidase (LPO) found in saliva, tears and airways protects system against bacterial and viral attack. It utilized hydrogen peroxide in the presence of halides or pseudohalide forming hypohalous acid a potent biocidal and virocidal agent. Melatonin is an important biomolecule that controls a number of functions including circadian sleep rhythms, blood pressure, oncogenesis, retinal function, seasonal reproduction, and immunity. Additionally, melatonin is frequently used as a supplement in a variety of medical conditions such as jet lag, shift work, and circadian rhythm sleep disorders, cancer, longevity and antioxidant therapy. Here, we demonstrate that melatonin modulates classic catalytic mechanism of LPO under physiological-like conditions. In the presence of chloride (SCN-), melatonin inactivated LPO classic peroxidase cycle by formation of compound II or two different intermediate compounds that are dead end products of LPO system. This behavior indicates that melatonin modulates the formation of LPO intermediates and their decay rates to the ground state this efficiently slowing down or inhibiting the cycling of the enzyme. Importantly, melatonin-dependent inhibition of LPO depends on hydrogen peroxide concentrations. Thus, the interplay between LPO and melatonin can have a broader implication especially in the cases of supplemental melatonin therapy.
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