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S.NO Title & Authors Name page
In vitro susceptibility of clinical uropathogens to levofloxacin at the Ghana police hospital
Daniel Kwame Afriyie, Martha Gyansa-Lutterodt, George Asare, Kwabena Agyekum, Edem Wormenor and Seth Kwabena Amponsah
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Background: Quinolones are among drugs used in the treatment of urinary tract infections (UTIs). However, there has been an increase in quinolone-resistant uropathogens over the last decade. The aim of this study was to assess the sensitivity pattern of isolated uropathogens to levofloxacin. Methods: Urine samples (n = 519) from suspected UTI patients were collected from July 2014 to September 2014. Microorganisms with significant growth were identified after initial culturing at 37°C for 24 hours. Susceptibility of isolated uropathogens to levofloxacin at a break point of 5 µg was done by the Kirby-Bauer disc diffusion method. Results: The prevalence of UTI among sampled patients was 18.3%. Predominant microbial isolates were: Escherichia coli (56.8%), Coliform spp. (24.2%) and Staphylococcus aureus (9.5%). Overall resistance of isolated uropathogens to levofloxacin was 51.6%. Levofloxacin resistance by predominant uropathogens was 63% for E. coli, 34.8% for Coliform spp. and 22.2% for S. aureus. Conclusions: High resistance of some isolated uropathogens to levofloxacin, especially with E. coli was observed in this study. Thus, the need for coordinated susceptibility monitoring of clinical isolates to levofloxacin.

Afriyie Kwame Daniel, Aryeetey Justus, Annoh Joseph, Darkwah Thomas, Dogbe Justice
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Pethidine is often used in management of moderate to severe pain which improves quality of life. Though used in several countries, its rational use is of concern due to its potential adverse effects. This cross-sectional descriptive study assessed pethidine utilization from 2012-2014, and prescribing trend from December 2014 to March, 2015 at the Ghana Police Hospital. Data collecting tools were used to obtain information on prescribing and utilization patterns at the dispensary within study periods. Of the 292 patient cards with pethidine analyzed, inpatients were 92.5 %, and 81% were on national insurance. Patients from the Obstetrics and gynaecology (80.5 %) had the highest proportion of pethidine prescription. Majority of indications and doses for which pethidine was prescribed were in line with National Guidelines. Proportion of annual pethidine usage to annual hospital utilization declined from 6.3 to 5.4%, in 2012 to 2014. Study revealed decline in pethidine use at the hospital, and its prescribing was with caution.