Country-wise Listing - Iraq

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S.NO Title & Authors Name page
1
Spectral and cytotoxic study of complexing mixed ligand formed by sodium [5-(P-nitro phenyl)-4-phenyl-1,2,4-traizole-3-dithiocarbamato hydrazide] and 1,10 phenanthroline with Fe(III) and Mn (II) ions
Mahasin Alias, Farah Saadoon, Maha Faisal, Nibras Mohammed, Caroline Shaker
 Abstract                  View                 Download                 XML
Mixed ligands complexes have been prepared by reaction of Sodium [5-(p-nitrophenyl)-\'4-phenyl-1,2,4-traizole-3-dithiocarbamato hydrazide] (L1) and 1,10-phenanthroline (L2) with Fe(III) and Mn(II) ions. The newly prepared complexes were isolated and characterized by FT-IR and UV-Vis spectroscopy, C.H.N., FAA technique, in addition to magnetic susceptibility and conductivity measurements. The nature of bonding between the metal ion and the donor atoms of the ligands were demonstrated by calculating of the ligand field parameters using suitable Tanaba-Sugano diagrams. Cytotoxic effect of the prepared complexes were evaluated against Hep-2 cell line using different concentrations (3000, 1500, 750 and 375 µg/ml) respectively in an exposure time 72 hrs comparing this effect with control positive Cis-Pt as reference drug.
47-52
2
COORDINATION OF SOME HEAVY TRANSOTION METALS COMPLEXES WITH 2-AMINO ACETIC ACID-6- METHOXY BENZOTHIAZOLE USING MICROWAVE AND THERMAL METHODS
Mahasin F. Alias, Basha\'ar A. Stephan and Farah S. Jaafer
 Abstract                  View                 Download                 XML
The ligand 2-amino acetic acid -6- methoxy benzothiazole (L) was prepared as a chelating ligand, which was treated with the ions Rh(III), Pd(II), Cd(II) and Pt(IV) in alcoholic medium in order to prepare series of new metal complexes. These complexes were prepared by conventional and microwave methods and characterized by the available techniques. FT-IR, UV-Visible, magnetic susceptibility, flame atomic absorption technique as well as elemental analysis and coductivity measurements. From the spectral studies, all complexes have square planer geometry except Cd complex have Td geometry. The nature of complexes in liquid state was studied by using molar ratio method and give results similar approximately to those obtained from isolated solid state; also, stability constant of the prepared complexes were studied and found that they were stable in molar ratio 1:1. A theoretical treatment of these compounds in gas phase was studied by Hyper Chem-8 program using Semi-empirical method. 
 
6-13
3
SYNTHESIS OF SOME D-GLUCOSE LINKED 1,2,3-TRIAZOLES AS UREASE INHIBITORS
Zeyad Kadhem oleiwi, Ezzat Hussein Zimam
 Abstract                  View                 Download                 XML
This research include synthesis of some new 1,2,3-triazole from D-glucose .The synthesis was started by preparation of phenyl propargyl ether derivative from the reaction of phenol with propargyl bromide . The second step of synthesis was performed by the click reaction of glycosyl azide of protected glucose with acetylenic ether to form 1,2,3-triazole derivatives. The biological activity of synthesized compounds were tested against urease activity. Some of these compounds (T1, T2,Tr3) show high inhibition action on the enzyme activity , while (T4)do not show any effect on the activity .
1037-1047
4
ACUTE TOXICITY, SPECTROSCOPIC AND MOLECULAR MODELING STUDIES OF SCHIFF BASE DERIVED FROM L-METHIONINE AND 2-HYDROXY-1-NAPHTHALDEHYDE
Wasfi A. Al-Masoudi, Mohammed A. Al-Diwan and Jalal A. Mojbal
 Abstract                  View                 Download                 XML
Condensation 2-hydroxy-1-naphthaldehyde 1 with L-methionine 2 yielded E-((2)-(((2-hydroxynapthalene-1-yl)ethylene)amino)-4-(methylthio)butanoic acid 3 in a good yield. The synthesized compound was characterized by elemental analysis, IR and 1H, 13C, HSQC, HMBC and ROSY NMR spectroscopy. The toxicity study of the synthesized analogue 3 was assayed for its LD50 value by using Dixon,s up and down method, which exhibited value of 477 mg / kg of body weight. Molecular modeling studies were performed, showing the hydrogen bending and hydrophobic interactions.
961-969
5
SYNTHESIS, SPECTROSCOPIC STUDY, THEORETICAL TREATMENT AND ANTIBACTERIAL ACTIVITY OF SOME TRANSITION METAL IONS WITH POTASSIUM (BENZOTHIAZOLE-2-DITHIOCARBAMATO HYDRZIDE)
Mahasin. F. Alias, Samar. A. Ahmed, Khalil I. Hussain, Carolin Shakir, Ayad. S. Hameed
 Abstract                  View                 Download                 XML
New metal complexes of the ligand Potassium (Benzothiazole-2-dithiocarbamato hydrzide) (L) with the metal ions Cr (III), Co (II), Cu (II), Pd (II) and Cd (II) were prepared in alcoholic medium. The prepared complexes were characterized by flame atomic absorption, FTIR, UV-Vis Spectroscopy, magnetic susceptibility and conductivity measurements. From these analysis, octahedral geometry was suggested for Cr (III), Cu (II) and Pd(II) complexes, while Co(II) and Cd(II) complexes have tetrahedral geometries, Structural geometries of these compounds were also suggested in gas phase by using hyper chem-6 program. PM3 was used to evaluate the vibrational spectra of the free ligand and these obtained frequencies agreed well with those values experimentally found. The antibacterial activity for the starting material, the ligand and its metal complexes were studied against two selected microorganisms staphylococcus aureus and pseudomonas aeruginosa using two different concentrations (10 & 5mM) in nutrients agar medium.
738-746
6
SYNTHESIS MIXED LIGANDS COMPLEXES OF SOME LIGHT METALS BY MICROWAVE ASSISTED USING 2-ACETAMIDE BENZOTHIAZOLE AND 1,10-PHENANTHROLIN
Mahasin F. Alias, Farah S. Jaafer and Amal S. Sadiq
 Abstract                  View                 Download                 XML
Mixed ligands of 2-acetamide benzothiazole L1 with 1,10-phenanthrolin L2complexesof  V(IV), Cr(III) , Co(II)and Ni(II )ions were prepared by microwave assisted radiation. The ligand and the complexes were isolated and characterized in solid state by using FT-IR, UV-Vis spectroscopy, flame atomic absorption, elemental analysis CHNS , magnetic susceptibility , melting points and conductivity measurements.2-acetamide benzothiazole behaves as bidenetate through carbonyl group and nitrogen atom of imine group. Fromthe analyses Oh geometry was suggested for NiL1L2, CrL1L2 complexes, square pyramidal for VL1L2 and Td for CoL1L2complex.A theoretical treatment of ligands and their metal complexes in gas phase were studied using HyperChem-8 program, moreover, ligands in gas phase also has been studied using Gaussian program (GaussView Currently Available Version (5.0.9) along with Gaussian 09 which was the latest in the Gaussian series of programs).
451-458
7
DETERMINATION OF POLYCYCLIC AROMATIC HYDROCARBONS, NITRATE AND NITRITE IN IRAQI VEGETABLES BY HPLC AND UV/VIS SPECTROPHOTOMETER
Abdal-Jabbar A. Ali, Khalil I. Hussain, Amera H. Hamed, Abood H. Moslah, Riyadh R. Neama
 Abstract                  View                 Download                 XML
This research deals with analytical methods for (16) polycyclic aromatic hydrocarbons (PAHs), nitrate and nitrite determination in Iraqi vegetables. Some PAHs are of proven carcinogenic activity; consequently, they exceed the limits of concentrations which approved by the European Food Safety Authority. Nitrate and nitrite also determined in Iraqi vegetables compared with the European specifications. There is no recommendations for the allowable limits of nitrate and Nitric in the fresh vegetables. The analytical determination for PAHs is carried out by high performance liquid chromatography, with ultraviolet (UV) detector, while the analytical determination for nitrate and nitrite is carried out by UV/Vis. Spectrometer.
165-171
8
Cytotoxicity Assay of Nickel and Cobalt (II) Complexes of 5-(4-Nitro Phenyl)-4-Amino-3-Mercapto Propenyl-1,2,4-Triazole on HepG2 Cell Line
Mahasin Alias, Ameena N. Seewan, Carolin Shakir, Farooq I. Mohammad
 Abstract                  View                 Download                 XML
Two new complexes with formula [M(NMP.TRZ)(H2O)3](NO3)2.3EtOH (where M is Ni and Co(II) ions respectively, NMP.TRZ is (5-(4-Nitro Phenyl)-4-Amino-3-Mercapto Propenyl-1,2,4-Triazole) have been synthesized by conventional method. These complexes have been characterized by spectroscopic methods such as (ultraviolet- visible and infrared), as well as to thermal gravimetric, metal analyses, microanalyses, conductivity, magnetic moment and molar ratio method. To measure the biologic activity and potential anticancer efficacy of these compounds, they have been compared with cisplatin on human hepatocarcinoma HepG2 cell lines in different eight concentrations (2000, 1000, 500, 250, 125, 62.5, 31.25 and 15.625 μg/ml) respectively, in the time of exposure 72 hrs. The results exhibit that the three prepared complexes i.e. ligand (NMP.TRZ) and its metal complexes have shown higher ratios cytotoxicities compared to cisplatin against HepG2 cell lines in most selected concentrations. Based on the obtained results of biological test, these compounds may be potentially being considered as good anticancer candidates for further pharmacological studies.
126-132
9
INVESTIGATION OF GENETIC DIVERSITY, AND RELATIONSHIPS AMONG A SET OF CLINICAL ASPERGILLUS FUMIGATUS ISOLATES USING SIMPLE SEQUENCE REPEAT POLYMERASE CHAIN REACTION (ISSR-PCR)
Batol Imran Dheeb, Saad Mohamed Nada, Yasamin Ali Hadi, Anas Nori Ibrahem, Ghufran Mohamed Hasan
 Abstract                  View                 Download                 XML
This study is an attempt to determine the genetic diversity and relationships among fourteen local isolate isolated from patients with Aspergillosis (Aspergillus fumigatus) by using the simple sequence repeat polymerase chain reaction (ISSR-PCR). Twelve universal primers used in this study produced 94 bands across fourteen isolates. Of these bands, 67 bands or 71.2% were polymorphic. The size of the amplified bands ranged between 100-2,000 bp. The genetic polymorphism value of each primer was determined and ranged between 33-100%. In terms of unique banding patterns, determine the finger print for six isolates the most characteristic banding pattern was for the (AFU1,AFU2,AFU3,AFU4,AFU8 and AFU14) with primer (RP F-16 , RP I-06, RP F-16, RP X-01, RP X-01and OP A-06). Genetic distances ranged from 0.12419 to 0.64404 among A. fumigatus isolates. Cluster analyses were performed to construct a dendrogram among studied A. fumigatus isolates.The cluster analysis places most of the A.fumigatus isolates isolated from patient come from yhe same area into a close relation (subcluster) showing a high level of genetic relatedness and were distinct from isolates from another area (the other subcluster). Interestingly, a number of isolates originating from the same sources did form well defined groups, indicating association between the ISSR patterns and the geographic origin of the isolates. The information generated from this study can be used in the future for controlling of Aspergillosis programs.
47-52
10
Cytotoxic Effect of Gliotoxin, Protease, and Melanin purified from Aspergillus fumigatus on REF Cell Line, in vitro Study
*Batol Imran Dheeb, Farooq Ibrahem Mohammad, Abdulkareem Jasim Hashim
 Abstract                  View                 Download                 XML
Aspergillus fumigatus especially clinical isolate produces a series of toxic substances and proteinicios hemolysin, protease and pigment like melanin which appear to act in an additive and synergic way on cells. In this study, gliotoxin, Protease, and Melanin were used in an experimental model to study their Cytotoxic activity by evaluating their effect on REF cell line ( Rat embryonic fibroblast ), on exposure time of  24  hrs at three different concentrations of  each compounds  triplicate of each concentration  were used, Cytotoxicity of the purified compounds are  active against REF cell line under study and a toxic effect was clear with a significant difference at the level of probability (p< 0.05) and this effect was contrasted among different concentrations for each purified compound growth inhibition of  REF cell line was increase gradually with the increase of compound  concentration.
675-679