Country-wise Listing - Italy

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S.NO Title & Authors Name page
1
QUALITATIVE AND QUANTITATIVE EVALUATION OF DIFFERENT PHARMACEUTICAL PRODUCTS CONTAINING QUETIAPINE: BRAND VERSUS GENERIC
Cristina Tomasello, Roberta Cavalli, Emanuela Peila, Marco Simiele, Anna Leggieri, Giovanni Di Perri, Antonio D\'Avolio
 Abstract                  View                 Download                 XML
Atypical antipsychotics are not only used for symptoms of schizophrenia, but also for the treatment of Behavioral Psychological Symptoms in Dementia. This work is focused on developing a selective, fast method for the quantitative and qualitative determination of quetiapine in Seroquel® 25mg and the generic Quetiapine 25 mg tablets. Analyses were conducted by dissolving tablets in a suitable solvent (water/ACN 50:50) and measuring the quetiapine amount using a UPLC-PDA instrument. Dissolution test, disintegration test, and thermal analysis were conducted with specific instrumentation according to the European Pharmacopea. Quantitative analysis showed that the difference between the two pharmaceutical products was about 0.055%, which is not statistically significant; qualitative analysis highlights a slight difference about the disintegration time (1 minute) and the dissolution, caused by different excipients. This is further confirmed by the thermal analysis (Differential Scanning Calorimetry). It is possible to conclude that no differences were identified among the reconstituted samples of the two different products containing quetiapine.
1-10
2
DETECTION AND ANALYSIS OF POSSIBLE INTERACTIONS BETWEEN DRUGS PRESCRIBED AT HOSPITAL DISCHARGE
*Bianchi Stefano, Bianchini Erica, Fedele Daniela and Scanavacca Paola
 Abstract                  View                 Download                 XML
Interaction between drugs constitutes a frequent cause of adverse drug reaction. The aim of this study, was to provide an analysis of potential drug interactions. The study groups were 225 patients from the dialysis unit and 519 patients from the heart failure centre. Discharge prescriptions from the two units were collected for six months during 2011. In the heart failure centre, 74% of patients received prescriptions for drug combinations that may have adverse interactions. The most frequent and important potential interactions concerned furosemide with enalapril,17%, and acetylsalicylic acid with metoprolol, 15%. In the dialysis unit, 19% of patients received prescriptions that may have adverse interactions. Two examples were algeldrate with amlodipine, 6%, In 1.3% of patients increase in INR occurred owing to interactions. The results have revealed particularly high risk for potential interactions in heart failure centre patients because of the prescription of many drugs and because of the types of these drugs.
290-295