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14-19 |
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442-449 |
3 |
Preclinical lipid profile studies of an ayurvedic preparation \"saraguna balijarita makaradhvaja\" used as antipyretic
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Md. Ashraful Alam, Shahnaz Jalil, Fariha Tasnim, Nahida Akhter, Mohsina Mukti, Md. Rakib Hasan, Satchit Neupane and MSK Choudhuri |
Abstract
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Saraguna Balijarita Makaradhvaja (SBM) is an Ayurvedic preparation used in traditional medicine as an antipyretic in the rural population. We were eager to know the effect of chronic administration of SBM on the lipid profile test. To find out the effect of chronic administration of SBM on the lipid profile, it was administered chronically to the male Sprague-Dawley rats at a dose of 400 mg/Kg. After 28 days of chronic administration of the SBM preparation, the following effects on the lipid profile were noted. There was a statistical significant increase in LDL and Non-HDL Cholesterol (p=0.01). A very highly significant (p=0.001) decrease was noticed in HDL-C level; thus leading to a statistically very highly significant (p=0.001) increase in Cardiac Risk Ratio (CRR) (TC/HDL-C), Castelli’s Risk Index-II (CRI-II) (HDL C/LDL-C) and Atherogenic Coefficient (AC) [(TC/HDLC)/ HDL-C)]. No significant change was found in case of TG, TC, VLDL and Atherogenic Index of Plasma (AIP) (log (TG/HDL-C)).
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18-22 |
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Adverse drug reaction following mass drug administration during the program to eliminate lymphatic filariasis in banke district, Nepal
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Upreti AR, Joshi D, Rijal B, Bharati L, Regmi BM |
Abstract
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This study aimed to find out types of adverse drug reaction following mass drug administration during the program
to eliminate lymphatic filariasis in Banke distict of Nepal.The retrospective study of the prescription of the patient
with the history of adverse drug reaction was done .The totals of 602 patient were reported to have adverse drug
reactions after intake of medication against filariasis under mass drug administration program. Nausea, Vomiting,
Abdominal pain, Fever, Diarrhoea, Malaise, Asthenia ,Angioedema , Dermatitis, Hydrocoel , Itching, Dyspnoea ,
Syncope, Convulsion, Anxiety were different types of adverse drug reactions reported during my study. Ethnic
variation in adverse drug reactions was also studied which shows disadvantage non dalit terai caste group had
highest reported cases of adverse drug reactions followed by religious minorities.
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62-67 |