Country-wise Listing - Philippines

To view the articles from different countries, Please click on the country name on left side countries menu.
S.NO Title & Authors Name page
1
THE CARDIOACTIVE SCREENING OF THE EXTRACT FROM THE BARK OF STROPHANTHUS CUMINGII A.DC. (APOCYNACEAE) USING ISOLATED FROG HEART
Maribeth R. Laurente, Mafel C. Ysrael
 Abstract                  View                 Download                 XML
Strophanthus cumingii A. DC. (Apocynaceae) is one of two endemic Strophanthus species in the Philippines the bark of which is used as an arrow poison [1]. Strophanthus species used for this purpose are known to contain cardiac glycoside strophanthin in the bark and seeds [2]. This study determined the cardioactivity of the bark extract S. cumingii and its sub-fractions on isolated frog hearts. The hexane fraction was the most cardioactive with a maximum of 30.58% increase in the force of contraction and 38.24% increase in the frequency of contraction. The non-polar fraction of the crude extract from the bark of S. cumingii elicited a positive inotropic and negative chronotropic effect on the isolated frog hearts.
1048-1050
2
IN VITRO ASSESSMENT OF THE ANTIOXIDANT AND ACETYLCHOLINESTERASE INHIBITORY ACTIVITIES OF FICUS NOTA (BLANCO) MERR.
Karen Gem D. Ares, Christelle Venus F. Capuno, Hannah Krizzia M. Cortes, Alyssa Trizia L. Cristi, Hilton Cedrick L. Cutero, Gamaliel P. Galigao, Librado A. Santiago, Sandra C. Sy
 Abstract                  View                 Download                 XML
Ficus species are known to exhibit neuroprotective activity and to some extent show acetylcholinesterase inhibitory activity. The aims of the study are to assess the antioxidant activity of the crude methanolic extract of the leaves of Ficus nota (Blanco) Merr. using scavenging assays for hydroxyl radical, nitric oxide radical, and hydrogen peroxide, and its acetylcholinesterase (AChE) inhibitory activity using Ellman\'s method. Phytochemical screening revealed the presence of terpenoids, tannins, alkaloids, polyphenols, and glycosides, and the total phenolic content (TPC) was found to be 3.448 mg/g GAE. The extract showed stimulatory activity towards hydrogen peroxide. On the other hand, inhibitory activity towards nitric oxide and hydroxyl radicals was exhibited in a decreasing trend. Furthermore, AChE activity was inhibited by the extract at low concentrations. The methanolic crude extract of the leaves of Ficus nota (Blanco) Merr. has pro-oxidant and AChE inhibitory activities. With these, the plant may be explored as a potential pharmaceutical substance in the future.
1020-1025
3
THE ANTISPASMODIC EFFECT OF Clerodendrum quadriloculare (Blanco) Merr. LEAF EXTRACTS
Kay Ann S. Jonatas-Tongol, Mafel C. Ysrael
 Abstract                  View                 Download                 XML
Clerodendrum quadriloculare, locally named bagawak morado decoction of leaves is used to relieve abdominal pain in folklore. However, scientific data on the biological activities of the plant are limited, thus prompting this research to provide in part the scientific basis for the plant’s reputed use for smooth muscle relaxant effects. The methanolic extract of Clerodendrum quadrilocualre was subjected to phytochemical analysis, toxicity test and smooth muscle modulating effects using isolated rat ileum. Phytochemical analysis by thin layer chromatography revealed presence of flavonoids, steroids, triterpenes, coumarins, tannins, phenolics and alkaloids. Toxicity study showed that C. quadriloculare is non-toxic at 5000 mg/kg. Organ bath studies of the isolated rat ileum showed that DCM fraction comparable relaxation activity of the acetylcholine-induced contraction (EC50=1376 µg/mL ± 0.03) as with the standard antagonist, Atropine (p > 0.05). The study indicates the potential use of Clerodendrum quadriloculare as a safe and effective treatment for smooth muscle spasm.
536-540
4
THE HEPATOPROTECTIVE ACTIVITY OF ALSTONIA MACROPHYLLA G. DON (APOCYNACEAE) AGAINST PARACETAMOL-INDUCED LIVER TOXICITY
Catherine Faith M. Romano, Librado A. Santiago
 Abstract                  View                 Download                 XML
To evaluate the hepatoprotective activity of crude ethanolic leaf extract of Alstonia macrophylla G. Don in Paracetamol induced hepatotoxicity in Sprague Dawley rats. Hepatotoxicity was established by induction of Paracetamol 500mg/kg leading to elevated liver markers, Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alanine phosphatase (ALP), and decreased Albumin levels. Single dose administration with Alstonia macrophylla crude extract (AmCE) on a 7-day duration treatment, resulted in decreased AST, ALT, and ALP and increased Albumin levels. Specifically the AmCE 600mg/kg resulted to significant effects at (p<0.01). Similarly, depleted levels of Glutathione, and Catalase levels were increased (p<0.003), (p<0.000), respectively. While Malondialdehyde – a measure of lipid peroxidation, was significantly decreased (p<0.000). Among the treatments, AmCE 600mg dose showed comparable effect with the standard drug N-acetylcysteine. This study demonstrated the hepatoprotective activity of the crude ethanolic leaf extract of Alstonia macrophylla.
380-383
5
WOUND HEALING POTENTIAL OF THE ETHANOLIC EXTRACT OF BANANA FLOWER (Musa sapientum, BBB ‘Saba’, Family Musaceae)
Rufo S. Calixtro, Jr., Analiza P. Malalay, Ponciano B. Epino and Lazaro E. Avelino
 Abstract                  View                 Download                 XML
The banana flower (Musa sapientum, BBB ‘saba’) ethanolic crude extract was investigated for its wound healing potential in vivo. Circular excision and linear incision wounds were inflicted on male Swiss mice, after which, they were treated with different concentration of banana extract. Betadine was used as the standard treatment. Significantly higher wound contraction is obtained when ethanolic extract was applied on the wound than the control. At ≥ 10% ethanolic extract, significant reduction in wound size is observed than betadine treated wounds. Similarly, a significantly higher tensile strength of the wounded skin of mice is obtained on ethanolic extract treated mice than the control. Tensile strength is significantly better at ≥ 15% ethanolic extract than betadine treated animals. Results indicate that banana flower ethanolic extract has a potential for use in healing wound.
33-37