Country-wise Listing - Republic of Macedonia

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S.NO Title & Authors Name page
1
DEVELOPMENT AND VALIDATION OF REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR DETERMINATION OF TIROFIBAN IN SERUM
Marija Darkovska Serafimovska, Emilija Janevik-Ivanovska, Zorica Arsova-Sarafinovska, Icko Djorgoski, Nenad Ugresic
 Abstract                  View                 Download                 XML
A specific, sensitive and rapid RP-HPLC method has been developed for the determination of Tirofiban in serum. The chromatographic separation was realized using reverse phase LiChrospher® 100 RP-18 column (4.0 mm × 250 mm, 5 μm) and mobile phase consisting the mixture of 0.1 M KH2PO4 (pH 5.2, adjusted with 1.0 N sodium hydroxide solution) and acetonitrile, with the ratio of 70:30% (v/v) and flow rate of 1.0 ml/min. The detection was carried out at 274 nm. The response was linear over the range of 0.03 – 0.18 mgmL-1 in mobile phase and serum samples. The limit of detection (LOD) for Tirofiban was 1.84, 13.8 and 14.6 μg mL-1 in methanol, spiked rat serum and spiked human serum, respectively. The described method can be quickly and routinely applied, without any interference from endogenous substances, for therapeutic monitoring of levels of Tirofiban in the serum samples.
115-120
2
DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR DETERMINATION OF KETOCONAZOLE IN PHARMACEUTICAL FORMULATIONS
Olga Popovska, Zoran Kavrakovski, Vesna Rafajlovska
 Abstract                  View                 Download                 XML
A UV spectroscopic method which is simple, accurate and rapid is developed for the determination of ketoconazole in pharmaceutical formulations as active substance in tablets, shampoos and cream. The absorption maxima of ketoconazole solutions in methanol are recorded at 244 nm and 296 nm. The linearity for ketoconazole in methanol with correlation coefficient values higher than 0.999 is found in the range of 0.005–0.025 mg/ml at 244 nm, R 2 = 0.9996 and 0.05–0.25 mg/ml at 296 nm, R 2 = 0.9996. The limit of detection (LOD) and the limit of quantification (LOQ) accounts to 0.000597 mg/ml and 0.00181 mg/ml at 244 nm and 0.00647 mg/ml and 0.01963 mg/ml at 296 nm, respectively. The intra– and inter–day assay is within 2% relative standard deviation. The obtained results for tablets, cream and shampoos are in good agreement with their respective product, label claims. The developed method can be successfully applied for the purpose routine analysis of ketoconazole in pharmaceutical formulations.
95-101
3
ASSESSMENT OF THE COMMUNITY PHARMACY PRACTICE IN THE REPUBLIC OF MACEDONIA - BUILDING PLATFORM FOR IMPLEMENTATION OF GOOD PHARMACY PRACTICE
Lidija Petrushevska-Tozi, Kristina Mladenovska, Jasminka Patceva, Th (Dick) Thromb, Kirsten Holme, Nina Sautenkova
 Abstract                  View                 Download                 XML
The objective of the study was to evaluate the actual status of the community pharmacy practice and quality of services and to identify the gaps and barriers to implement the best pharmacy practice and care. Cross-sectional descriptive survey was conducted for the pharmacies/pharmacists where pre-coded multiple choice closed questions were used with response format: activity fully applied, partially applied, applicable or not applicable. Set of 155 indicators was developed covering five essential components: pharmacy structure and practice; patient safety; manufacture practice; staff workflow and competences and quality assurance. The actual score was 64 out of 100. Pharmacy services related to manufacture practice and quality assurance were identified as the areas of highest priority for improvement, followed by the services related to patient safety. Priorities for intervention by key stakeholders (national authorities, academia, professional associations and pharmacists) and recommendations for introducing new and improving the existing roles of the pharmacists were defined.
1-9