Country-wise Listing - Srilanka

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S.NO Title & Authors Name page
1
Dissolution incompatibility of Paracetamol as a silent dissolution retardent of concomitantly administered drugs
Kithmini Yasarathna, Chamodi Wijesinghe, Banukie Jayasuriya, Walisinghe Pathirana.
 Abstract                  View                 Download                 XML

 

High strength tablets containing 500 mg or more active ingredients could affect the dissolution of concomitantly administered drugs. Dissolution of ten generic solid dosage forms was determined in the presence of sodium bicarbonate and paracetamol, 500 – 2250 mg. In a total of 111 dissolution tests 41 failed (37%) to meet the criteria. Where paracetamol was present 36 out of 50 end points failed (72%) with an extreme case in diltiazem tablets with 0% dissolution. Since longest test end points with failures mostly range from 60 – 90 minutes it is advisable to administer paracetamol 1.5 hours after other drugs in order to avoid potential pharmacokinetic disturbances.a
 

38-49
2
PRELIMINARY INVESTIGATION INTO COMPARATIVE TRANSCRANIAL BRAIN TARGETED AND TRANSDERMAL SYSTEMIC EFFECTS OF DIAZEPAM ON SLEEP LATENCY
Walisinghe Pathirana, Sudath Gunasekera, Godwin Constantine, Yashasvi Sanja Perera, Wedisha Gankanda, Malsha Gunathilaka, Sandamali Senanayake and Janaki Kumari
 Abstract                  View                 Download                 XML
Emissary veins that drain blood from the scalp into sinuses of the brain are a potential route for targeted central nervous system drug delivery. Structure of the scalp, cranial bones and cerebrospinal fluid flow indicate that they can facilitate transcranial drug delivery. A cascade for the transcranial drug diffusion is proposed. Diazepam 2 mg/3 ml of sesame oil was administered transcranially and transdermally in order to investigate brain targeting in human volunteers. Sleep latencies were monitored with Multiple Sleep Latency Tests involving 5 Naps employing standard electroencephalography, electroocculography and electromyography electrodes. The six volunteers were subjected to four days of electroencephalography screenings for the base line, placebo oil, diazepam on scalp and diazepam on forearms. The mean sleep latencies for the Nap 3 with peak responses were 13.8, 8.7, 5.9 and 7.7 minutes respectively indicating that the transcranial brain targeting of diazepam is possible.
37-46
3
GROUP 18 CENTERED PERIODIC TABLE WITH ENHANCED INTERPRETATIONS IN CHEMICAL, PHARMACEUTICAL AND LIFE SCIENCES
Walisinghe Pathirana
 Abstract                  View                 Download                 XML
The periodic table was dissected between groups 12 and 13 followed by realigning groups 1 and 18 next to each other while ensuring proper sequencing of atomic numbers. The table now assumed a peak form. All the important elements in chemical, pharmaceutical and life sciences were captured around the peak within a v-shaped area near the table center. A useful bilateral feature emerged with elements having broadly different properties lying on either side of group 18. The new periodic table was found to represent a replica of a cross section of the earth’s crust and to some extent advanced animal forms. A well-defined position was identified for atomic number 0 assigned with symbol 0Ec. The scope for new interpretations in chemical, pharmaceutical and life sciences are possible to a greater depth and clarity.
37-44