Country-wise Listing - Turkey

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S.NO Title & Authors Name page
1
Feedback of pharmacy students toward teaching-learning pharmacology in Northern Cyprus
Sonia SANAJOU, louai Mohammad ALSALOUMI, Bilgen BASGUT
 Abstract                  View                 Download                 XML

This study explores pharmacy students’ feedback on teaching–learning methods of pharmacology in faculties of pharmacy in Northern Cyprus universities. 150 students randomly selected and participated by filling self-administered questionnaires. The majority of participants were female and most of them were in the 4th year of their study. The results showed that high percentage of students had good understanding and grasping of pharmacology subjects in class, and the pharmacology is the most favored course in comparison with others. Moreover, participants taught that pharmacology course will have most usage in their future pharmacy practice. It can be concluded that the general attitude of students toward pharmacology were positive; however, some changes in curriculum are still required in order to make the pharmacology courses more interesting.

1-12
2
OBSERVATION OF RADIOTHERAPY RELATED ACUTE SIDE EFFECTS´ OCCURRENCE AND MANAGEMENT IN CANCER PATIENTS
Anmar Al-taie, Aygül Köseoğlu, Fikret V.Izzettin, Songül Tezcan, Tayf Alqozbakr, Atin Aksu
 Abstract                  View                 Download                 XML
The aim of this study was to observe the most common radiotherapy related acute side effects and the effective modulating treatment of these side effects in cancer patients undergoing radiotherapy. A randomized retrospective study was carried out on 79 cancer patients admitted at the radiology unit. Radiotherapy related acute side effects and specific therapies were documented and assessed. The major acute side effect was diarrhea 82, 3%. While, 48, 5% of mucositis, and 62, 5% of skin reactions were managed by benzydamine mouth wash and dexpanthenol ointment respectively. A significant correlation observed between gender and skin reactions (males 55, 6%, females 83, 3%); previous chemotherapy with appetite loss (25%) and with metallic taste (60%). Concerning radiation-applied area, mucositis and stomatitis were significantly correlated with both thorax (39, 2%, 33, 1%), and head (31, 4%, 33, 1%) areas respectively. The occurrence of radiation related acute side effects indicates both the essentially for follow-up and the potential role of clinical pharmacist for better outcomes.
11-19
3
DEVELOPMENT AND COMPARATIVE EVALUATION OF THEOPHYLLINE LOADED EXTENDED RELEASE CAPSULE
Mehmet Ali Ege, Tamer Guneri
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The aim of the present study was to develop a new theophylline hard gelatin capsule drug delivery formulation. The formulation have been prepared to enhance its dissolution which could provide better oral absorption of theophylline. Therefore, the effects of the component nature and their proportion in the release rate were investigated. Extended release capsules of theophylline were prepared by physical mixing using HPMC and cellulose acetate phthalate (CAP) at various drug-polymer ratios. Hydroxy propyl methyl cellulose (HPMC-E50) ratio was changed the release profile of theophyline. The optimum CAP % was selected as 75 % according to in vitro release studies. Flow properties of the F8 physical mixtures were evaluated by calculation of the Carr’s index, angle of repose and Hausner ratio.The results of the study indicate that new extended release hard gelatin capsules can be promising alternative for the other oral formulations of theophylline.
33-38
4
NON CHOLESTEROL LOWERING DOSE OF ATORVASTATIN AMELIORATES DIABETIC VENTRICULAR MYOCYTE DYSFUNCTION IN MICE
Gulgun Ozansoy, Aslı Ceylan-Isık, Fugen Aktan, Ahmet Cumaoglu, Aysel Arıcıoglu, Cimen Karasu, Nuray Arı
 Abstract                  View                 Download                 XML
The aim of this study was to investigate whether atorvastatin ameliorates diabetes-induced cardiomyocyte dysfunction, independently of cholesterol-lowering effect. Streptozotocin-induced diabetic mice were treated with atorvastatin (10 mg/kg, daily, orally) for two weeks. Ventricular cardiomyocytes were isolated and contractile properties including peak shortening (PS), time to PS (TPS), time to 90% relengthening (TR90) and maximal velocity of shortening/relengthening (+/- dL/dt) were analysed using video-based edge detection. Diabetes caused mechanical dysfunction with dampened stress tolerance of myocytes at high stress frequencies, all of which were significantly alleviated by atorvastatin without affecting hyperglycemia and dyslipidemia. In addition, changes in oxidative stress parameters (CAT activity, GSH and MDA levels) were also normalized by atorvastatin. These data indicate that atorvastatin, independently of its lipid-lowering capacity, reduces myocardial oxidative stress resulting in improved myocyte mechanical function in an experimental model of diabetes. Our results supports the concept that restriction of myocardial oxidative stress is a fundamental goal in the treatment of diabetic cardiomyopathy.
23-32
5
PREPARATION AND CHARACTERIZATION OF NAPROXEN LOADED MICROEMULSION FORMULATIONS FOR DERMAL APPLICATION
Neslihan Ustundag-Okur, Mehmet Ali Ege, H. Yeşim Karasulu
 Abstract                  View                 Download                 XML
Ficus glomerata Roxb (Branches) is a rich source of phenolic compounds known to possess potential antioxidant activity offering numerous health benefits. The present study evaluated the protective effects of methanol extract of Ficus glomerata at two doses (FG250; 250 mg kg-1 and FG500; 500 mg kg-1 ) against benzo(a)pyrene (BaP) induced gene expression changes and DNA damage in male mice. Fifty adult albino male mice allocated in five groups were used in this study. Benzo(a)pyrene (BaP) administration resulted in significant increase (P ≤ 0.01) in the gene expression of liver cancer-related genes (CYP1A1, CYP1A2, CYP3A4, CYP2B6, CD59, hTRET and P53) in hepatic tissues of male mice. In addition, (BaP) increased the rate of DNA damage in mice blood cells. Extract pretreatment restored genetic alteration parameters toward normalization. FR250 and FR500 decreased the gene expression alterations and rate of DNA damage induced by BaP in male mice. Extract pretreatment, 500 mg kg-1 , was more effective in reducing the genetic toxicity than the extract, 250 mg kg-1 . BaP exposure resulted in pronounced oxidative stress, and administration of Ficus glomerata extract offers significant liver and blood cells protection by inhibiting the changes of gene expression and damage of the DNA through scavenging free radicals.
33-42
6
ANTIDIABETIC ACTIVITY OF THE AQUEOUS EXTRACT OF ANCHUSA STRIGOSA LAB IN STREPTOZOTOCIN DIABETIC RATS
*Ahmed Muhammed and Nuray Arı
 Abstract                  View                 Download                 XML
Flowers of Anchusa strigosa Lab. (Boraginaceae) used traditionally in Iraq for curing many kinds of diseases including diabetes. The present study was carried out to evaluate the antidiabetic activity of aqueous extract of flowers of A. strigosa in streptozotocin (STZ)-diabetic rats. The aqueous extract of A. strigosa flowers was administered orally (250 mg/kg and 500 mg/kg) to diabetic rats for 30 days. A. strigosa caused a dose-dependent fall in blood glucose. Also there was an improvement in serum insulin levels. Cholesterol and triglyceride levels showed significant reduction in comparison with diabetic control group. The extract treatment also showed significant increase in hepatic glycogen levels. The results suggest that A. strigosa possesses antidiabetic effects in STZ-induced diabetic rats.
445-449