Country-wise Listing - Zambia

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S.NO Title & Authors Name page
Pathophysiology and Pharmacotherapy of Persistent Post- Infectious Cough: A Review of Literature
Lavina Prashar and Christian C Ezeala
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Persistent post-infectious cough (PPC) is a subacute cough lasting less than 8 weeks.  This article aims to review recent advances in the pathophysiology and pharmacotherapy of PPC secondary to upper respiratory tract infection.  Between April and August, 2016, relevant databases were searched using the search words “subacute cough,” “persistent post-infectious cough,” “post-viral cough,” “causes,” pathogenesis,” and “management.” Inflammatory mechanisms play a reported role in the pathophysiology of PPC. Interplay of mediators such as neuropeptides, cysteinyl leukotrienes, Th1-like and Th2-like cytokines and gamma interferon, has been suggested. Combination of ‘Honey and ‘Coffee’ and Suhuang Zhing, a traditional Chinese medicine is reported to demonstrate clinical efficacy in clinical trials. Natural products and herbal medicines appear to be superior to conventional treatments.

Effects of Vernonia Amygdalina Leaf Extract on Total Antioxidant Capacity and Malondialdehyde Levels in Acetaminophen-Induced Toxicity in Mice
Mweenda Sitanimezi, Ezeala Christian Chinyere, Prashar Lavina
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Background: Many plants have been shown to possess antioxidant properties. Aim: To determine the effects of V. amygdalina on Total antioxidant status and malondialdehyde levels in mice treated with acetaminophen overdose. Methodology: Mice were separated into 5 groups of 6 mice each. 300mg/kg of acetaminophen was administered to all groups except group 1. Then V. amygdalina extract was administered to groups 1 and 3 at 50mg/kg and group 4 at 100mg/kg, and group 5 received Vitamin C at 500mg/kg, all treatments were given orally. 8 hours later blood samples were collected by cardiac puncture, livers were excised, homogenised and used for biochemical analysis.  Results: Acetaminophen produced a significant reduction in TAOC and a marked increase in MDA levels of mice in groups 2, 3, 4 and 5. These effects were significantly attenuated by V. amygdalina administration, in a dose dependent manner. These effects were comparable with those of Vitamin C. Conclusion: Results suggests that Vernonia amygdalina possesses significant antioxidant effects.