*Girish P. Laddha and G. Vidyasagar There are number of patients suffering from of psychiatric condition such as depression, anxiety, schizophrenia, migraine, anti-impulsivity, cognition. Serotonin is the most important neurotransmitters that have been implicated in etiology of number of these psychiatric conditions. Ethyl acetate soluble fraction and insoluble of leaves extracts of morus Alba was carried out on different in-vitro methods.  Laboratory animals were given lithium sulphate to causes serotonin blockage from serotonergic neurons. They were treated with different higher concentration clozapine (active comparator) and EASF and EAISF then the psychotic symptoms were monitored to see which group exhibited the best response. The highest dose extract (100mg/kg) was comparable to clozapine in lowering psychotic behavior characterized by head twitches, stereotypy and 5-hydroxytryptophan potention hence both morus Alba and clozapine can be used to treat psychosis induced by amphetamine. The anti-psychotic effect of morus alba leaves may be in dose graded fashion. <br /><br /> International Journal Of Pharmacy 2249-1848 96 2012-07-01 3 513-519 Copyright (c) Pharma Scholars. All rights reserved 2013