DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF NEBIVOLOL AND VALSARTAN IN PURE BULK AND PHARMACEUTICAL DOSAGE FORM
D. Sreelatha, R. Ramya and T. Ramarao
A simple, Accurate, precise method was developed for the simultaneous estimation of the Nebivolol and Valsartan in Tablet dosage form. Retention time of Nebivolol and Valsartan were found to be 2.496min and 3.905min. %RSD of the Nebivolol and Valsartan were and found to be 0.4 and 0.8 respectively. %Recover was Obtained as 99.52% and 99.93% for Nebivolol and Valsartan respectively. LOD, LOQ values are obtained from regression equations of Nebivolol and Valsartan were 0.070ppm, 0.2142ppm and 0.179ppm, 0.544 ppm respectively. Regression equation of Nebivolol is y = = 0722x + 144.0, and y = 4560x + 248.2 of Valsartan . Retention times are decreased and that run time was decreased so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.
International Journal Of Pharmacy
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