Yutaka Inoue, Misa Horage, Rina Suzuki, Daichi Niiyama, Ryota Urano, Shigeru Ando, Junko Kikuchi, Isamu Murata, Ikuo Kanamoto <p [removed] justify;\\\"> The aim of this study was to assess the physicochemical properties of a solid dispersion of L-ascorbyl 6-palmitate (ASCP) as poorly water soluble and ?-cyclodextrin (?CD) prepared by co-precipitation or co-grinding by using powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (solution state 1H-NMR and solid state 13C-NMR), and solubility test. Physical assessments and measurements indicated that a co-precipitate of ASCP and ?CD resulted in inclusion complex formation at a molar ratio of 1:3 and that a ground mixture of ASCP and ?CD resulted in inclusion complex formation at a molar ratio of 1:2. A solubility test revealed that the co-precipitate and ground mixture had improved solubility compared to ASCP alone. The co-precipitate had greater solubility than the ground mixture. This result is presumably due to molecular interaction occurring as result of the differences in the molar ratios and differences in the structure of complexes for ASCP and ?CD in a solid state.</p> International Journal Of Pharmacy 2249-1848 826 01/05/2017 1 9-21 Copyright (c) Pharma Scholars. All rights reserved 2013