Smaail Radi, Said Tighadouini, Olivier Feron, Olivier Riant, Yahia Nasser Mabkhot, Salim S. Al-Showiman, Taibi Ben Hadda, Mohammed El-Youbi, Redouane Benabbes, Ennouamane Saalaoui A series of Schiff bases of furan and thiophen rings has been synthesized in one step, in good and excellent yields, using acetic acid as catalyst. The synthesized products were evaluated for their anticancer activity toward breast (MDA-MB231) and colorectal (LoVo) human cell lines cancers. The in vitro antibacterial and antifungal potential of the products were also determined using tree bacterial strains (Echerichia coli, Bacillus subtilis, and Micrococcus luteus) and fungal strains (Fusarium oxysporum f.sp albedinis FAO). Significant activity against breast cancer cell lines and Fungal strains was observed. International Journal Of Pharmacy 2249-1848 491 2015-01-02 1 39-45 Copyright (c) Pharma Scholars. All rights reserved 2013