Qasem M. A. Abdallah, Mahmoud S. M. Al-Haddad, Omar H. M. Al-Khathami, Omar H. H. Al-Kherish, Khaled M. T. Al-Marri, Mohammaed F. K. Al-Matani, Amjad M. N. Al-Rashed Impropriate disposal of medicines can lead to increase security, health and environmental risks. In this study, we evaluated the awareness and pattern of practice regarding drug disposal among university students in the Western Region of Saudi Arabia. A Cross-sectional research design using convenience sampling technique was used in this study. 1446 respondents successfully responded to this study.More than Three quarter (76.9%) of which have had the experience of discarding drugs. Discarding unwanted medicines via household waste baskets was the most popular method followed by disposing drugs via drainage. Only a quarter of respondents have previously received information about how to dispose medicines. Drug dosage form and amount of drug were important factors.Low awareness level of respondents and the lack of systems instructing the re-collection of unwanted household medicines may be the main reasons linked to theirrational method of drug disposal. Not failing the importance of awareness programs, introducing such drug-disposal systems would improve the outcomes. International Journal Of Pharmacy 2249-1848 440 2014-10-02 4 14-21 Copyright (c) Pharma Scholars. All rights reserved 2013