ANTIHYPERLIPIDEMIC OF RUELLIA TUBEROSA LINN IN TRITON INDUCED HYPERLIPIDEMIC RATS

Krishna Chaitanya B, Ravindra Babu S, Jayasree Vardhan, Alekhya Ravellaa, Diana Vivian Atigaria, Jaji Sree

Hyperlipidemia is the greatest risk factor of coronary heart disease. The present study was designed to investigate the antihyperlipidemic activity of Ruellia tuberosa ethanolic extract (RTEE 2012) in Triton X-100 induced Hyperlipidemic rats. RTEE 2012 was administered at a dose of 250, 500 and 1000mg/kg, (p.o) to Triton induced Hyperlipidemic rats. Atorvastatin is used as reference standard. The statistical analyses were carried out using one way ANOVA. RTEE 2012 show a significant decrease in the levels of serum cholesterol, triglycerides, LDL, VLDL and significant increase in the level of serum HDL with increase in dose of RTEE 2012 against Triton induced hyperlipidemic rats. Therefore it effectively suppressed the Triton induced hyperlipidemia in rats, suggesting the potential protective role in Coronary heart disease.