DESIGN, CHARECTERIZATION AND IN-VITRO, IN-VIVO CORRELATION STUDIES FOR ELETRIPTAN LOADED TRANSDERMAL PATCHES

P. Praneetha*, Sowjanya Battu, V. Umamaheshwar Rao, A. Ramyasree

Eletriptan is a 5-HT1D (5-hydroxy tryptamine 1D)-receptor agonist, used in the treatment of migraine and cluster headache. Eletriptan has been shown to have a low oral bioavailability in human volunteers (50%) because of high first pass metabolism. The present investigation is to formulate matrix type transdermal drug delivery system which is loaded with Eletriptan using Hydroxy Propyl methyl cellulose k-4 and k-15 individually as a release controlling polymers, Propylene glycol as permeation enhancer and Dibutylpthalate as a plasticizer. The prepared patches were characterized by diffusion studies with Franz diffusion cell and further correlated with animal studies. The work was aimed to develop the TDDS which controls the release of Eletriptan for 48 hrs. The models used were zero and firstorder equations, Higuchi and Korsmeyer-Peppas models. Based on physicochemical properties and in vitro release studies, patch containing Hydroxy propyl methyl cellulose k15(500mg) emerged as a best formulation. Skin irritation studies for the transdermal patches were assessed and were found to be free of irritation.