DESIGN, DEVELOPMENT AND DISSOLUTION ENHANCEMENT OF SIMVASTATIN WITH POLOXAMER 407 BY KNEADING METHOD

1Taranjit kaur, 2Harpreet Singh*

The aim of the present study was to enhance the solubility and dissolution rate of Simvastatin (SIM) under the frame of improved bioavailability and dissolution rate. Solid dispersion of SIM was prepared by using LBG, PXM407 as carrier in different ratios through Kneading method. A 32 full factorial design was applied systematically and effect the influence of the individual and combined effect of independent variables (X1) ratio and (X2) concentration of surfactants on the dependent variables percent dissolution efficiency at 60 min (%DE 60) and yield percent. The solid dispersions and optimized formula was characterised on the basis of drug content analysis, %yield and in vitro dissolution study, Differential scanning calorimetry, Scanning transmission microscopy, X-ray diffraction and IR spectroscopy was performed to identify the physicochemical interaction between drug, carrier and other formulation constituents. Results showed that significantly better dissolution rate of solid dispersion SIM with PXM407 in the ratio of 1:8. This study could be very much helpful for better bioavailability and dissolution rate of poorly water soluble drug avoiding first pass metabolism.