EFFECT OF BACOPA ON MEMORY DEFICIT PRODUCED BY CHRONIC ADMINISTRATION OF TOPIRAMATE IN RATS

Deval K, Vaibhav S, Krishna KL

Epilepsy is a most common disease mainly occurring in children and elderly patients. Cognitive disorders are common in patients, who are under the treatment of epilepsy. Topiramate is, one of the widely used anticonvulsants, is known to adversely affect cognitive function. In this context we have studied the memory deficit function of Topiramate on chronic administration in albino rats. Topiramate was administered for successive 14 days in rats. Bacoppa monniera extract powder (BM) 20% was co-administered along with topiramate from 8th day of treatment. Morris water maze was employed to evaluate learning and memory using parameter like Escape Latency Time (ELT), Time Spent in Target quadrant (TSTQ) and estimation of brain Acetyl cholinesterase level. Anticonvulsant activity of Topiramate was evaluated in presence of BM on PTZ induced convulsion and MES induced convulsion in rat model. Topiramate has significantly produced memory deficit in rats as it increases ELT, decreases TSTQ and increases AchE levels. When BM was given along with Topiramate from the 8th day of treatment, significantly reversed Topiramate induced impairment as it decreases ELT, increases TSTQ and decreases AChE levels. Even when BM co-administered with Topiramate, it did not interact with Topiramate and Topiramate retain its anticonvulsant activity. The results provide evidence for potential corrective effect of BM in cognitive deficit associated with TP.Int J Pharma