EVALUATION OF DIURETIC ACTIVITY OF POLYHERBAL FORMULATION

Vaijayanthimala Palanisamy*, Sureshkumar Shanmugam, Sangameswaran Balakrishnan

The present study was carried out to investigate the diuretic effect of ethanol extract of the leaves of Trichosanthes cucurmena L. (EETC), Cucumis sativus L.(EECS) and fruits of Corriandrum sativum L. (EECRS) to make a poly herbal formulation (PHF) and were administered to experimental rats orally at the dose level of of 150mg/kg and compared with standard drug Furosemide (20mg/kg). The diuretic effects of the extracts and PHF were evaluated by measuring the parameters like urine volume, sodium, potassium and chloride contents. The lipschistz method used in rat for the experiment purpose. The extract and PHF showed a marked level of increase in urine volume and electrolytes like Na+, K+ and Cl- ion concentration. The moderate diuretic effect was observed and significant diuretic effect from PHF. PHF (150mg/kg) showed more diuretic effect than standard. This might be the first formal report on diuretic effects of these three plant combinations.