FORMULATION AND EVALUATION OF BILAYER FLOATING TABLETS OF CIPROFLOXACIN AND ALOE VERA GEL POWDER FOR TREATMENT OF GASTRIC ULCERS

M. Yasmin Begum*, G.Prathyusha Reddy, Chitampally Sirisha, V.Lakshman rao, Muvvala Sudhakar

The aim of the present work was to design and develop a bilayer floating tablet of Ciprofloxacin and Aloe vera gel powder for the treatment of peptic ulcer, with the objective of retaining the dosage form in stomach for better antiulcer activity using the synthetic drug with a herbal product. Aloe vera gel powder was used for its cytoprotective action. Six Bilayer floating formulations were prepared by using direct compression method.The formulation has been developed using hydroxypropyl methyl cellulose HPMC K4M and HPMC K100M at varying concentrations. FTIR studies showed no incompatibility between the drug and excipients. The ratios of sodium bicarbonate and citric acid was adjusted to get the least possible lag time less than one minute with good matrix integrity and total floating log time greater than eight hours. Among all the six formulations F4 showed the maximum drug release of 96.018% within eight hours.