FORMULATION AND EVALUATION OF CORDIA DICHOTOMA FRUIT MUCILAGE AS MATRIX FORMING AGENT FOR SUSTAINED RELEASE OF PROPRANOLOL HYDROCHLORIDE

D. Lohithasu*, A.V.S. Madhu Latha, D. Midhun Kumar and P. Girish

The objective of the present study was to design sustained release tablets of Propranolol HCl by direct compression using HPMC K 100 M and Cordia dichotoma fruit mucilage. Tablets were prepared by direct compression method and prepared tablets were subjected to physicochemical studies, in vitro drug release kinetic studies and stability studies. FTIR studies were shown that, there was no interaction between drug and polymer. The physicochemical properties of tablets were found within the limits. The optimized formulation (F6) was subjected to stability studies for three months at 40 Ë?C, RH 75 ± 5 % and showed there were no significant changes in drug content, physicochemical parameters and release pattern. The kinetic treatment of selected formulation (F6) showed that the release of drug follows Higuchi models. The obtained results of the present study indicated that Cordia dichotoma fruit mucilage as matrix former in sustained release formulation of Propranolol HCl.