FORMULATION AND EVALUATION OF ZOLMITRIPTAN FAST DISSOLVING TABLET USING SYNTHETIC SUPERDISINTEGRANTS

Ch. Saidulu*, M. Jhansirani, R. Aruna, A.M.S. Sudhakar babu

In recent decades, a variety of pharmaceutical research has been conducted to develop new dosage forms. Among them, the fast disintegrating tablet (FDTs) is one of the most widely employed commercial products to facilitate ease of medication. Upon introduction into the mouth, these tablets dissolve or disperse in the mouth in the absence of additional water and the active pharmaceutical ingredients are readily released from the dosage form. In present study Zolmitriptan tablets were formulated by using synthetic superdisintegrant namely Amberlite, Sodium starch glycolate and Indion in different ratio then compared with marketed Zolmitriptan tablets were prepared namely F1 to F10 formulation and these are characterized by hardness, thickness, weight variation, friability, wettability time and dissolution studies. Fast dissolving tablets can be prepared by direct compression method using synthetic superdisintegrant. The values obtained from the evaluation studies indicate that all the parameters within the standard limits. In vitro disintegration studies showed that fast dissolving tablets from F9 (Indion 1:3 ratio) showed the best disintegration time with in 32sec. In vitro dissolution studies showed that the formulation F9 gave the maximum percentage drug release (100%) with in 7min.