Importance Protein Kinase C Inhibitorâ??s as a Potential Therapeutic Target for the Treatment of Bipolar Disorder

Abdul MR; Ramakrishna D; Shashidhar P; Mehnoor F; Faheemuddin M

Abstract

Importance Protein Kinase C Inhibitor�??s as a Potential Therapeutic Target for the Treatment of Bipolar Disorder

Abdul MR, Ramakrishna D, Shashidhar P, Mehnoor F, Faheemuddin M

Bipolar disorder is a challenging illness for the family, society and to the person suffering from it. According to the previous preclinical and clinical data suggest the role of PKC signaling pathways in the Pathophysiology of bipolar disorder. Generally bipolar disorder is associated with over active PKC intracellular activity. Knowledge is crucial for the development of specific targeted therapies that are more effective and that have more rapid onset of action than currently available treatments. Currently used medication for the treatment of bipolar disorder like lithium and valproate indirectly inhibit PKC activity. So the development of CNS penetrates PKC inhibitors can be considered as a potential target for the management of bipolar and maniac disorder.