Abstract
NEW ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF GEMFIBROZIL IN BULK AND PHARMACEUTICAL FORMULATION BY RP-HPLC
*A. Sushma, K. Harinadha Babu and G. Vijay Kumar
A simple, specific and accurate reverse phase high performance liquid chromatographic method was developed for
the determination Gemfibrozil in bulk and pharmaceutical dosage form. The column used was Agilent Zorbax C8
(150 ×4.6mm, 5μ) in gradient mode, with mobile phase containing Solvent-A: phosphate buffer adjusted the pH-
3.0 with orthophosphoric acid Solvent-B: Methanol the flow rate was 1.5 mL/ min and eluents was monitored at 276
nm. The retention time Gemfibrozil was 5.158 min, respectively. The linearity for Gemfibrozil was in the range of
30-450 μg/ml respectively. The recovery of Gemfibrozil was found to be 99.5%, respectively. The proposed method
was validated and successfully applied to the estimation of Gemfibrozil in capsule dosage form.
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