NEW PYRIMIDINE AND FUSED PYRIMIDINE DERIVATIVES: SYNTHESIS AND ANTI HEPATITIS A VIRUS (HAV) EVALUATION

Ahmed Ali El-Sayed*, Mahmoud El-Shahat, Samira T. Rabie, Eman M. Flefel, Dina N. Abd-Elshafy

Some novel fused pyrimidine derivatives 5–14 were prepared starting with compound 4. Also, Ethyl 4-(2,5-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 2 was used for the preparation of some fused pyrimidine analogs 15–19. All synthesized compounds were evaluated for their antiviral activity against HAV virus by determination of plaque infectivity count assay on HepG2 cells. Compound 7 has high antiviral activity against HAV even higher than Amentadine (positive control) and on studying its mechanism of action it showed combined action between adsorption and replication of HAV.