PRECLINICAL BLOOD CHEMISTRY SAFETY PROFILE STUDIES OF �??BASANTA KUSUMAKAR RAS�?� AFTER CHRONIC ADMINISTRATION TO MALE SPRAGUE-DAWLEY RATS

Kamrun Nahar, Md. Rakib Hasan*, Sumon Kanti Chowdhury, Paritosh Chakma, Gulshanara Begum, Nawfel Abdullah, Md. Moklesur Rahman Sarker and M. S. K. Choudhuri

Basanta Kusumakar Ras (BKR), an Ayurvedic preparation is used as a traditional medicine in the treatment of Diabetes mellitus. We were eager to know the effect of chronic administration of BKR on the lipid profile, liver function test and kidney function test. To find out the toxicological characteristic of BKR, it was administered chronically to the male Sprague-Dawley rats at a dose of 400 mg/kg. After 28 days chronic administration of the BKR preparation the following toxicological changes were noted. There was a statistically significant increase in serum total cholesterol (TC) and LDL-C level besides a statistically significant decrease in serum HDL-C level; thus leading to a statistically significant increase of both Cardiac Risk Ratio (TC/HDL-C) and Castelli’s Risk Index (LDL-C/HDL-C). There was a statistically significant increase in both bilirubin and creatinine level. Chronic BKR administration revealed dyslipidemia, possible loss of liver function and kidney function.